Intractable Neuropathic Pain
- Chronic Pain for more than three months
- Chronic Pain caused by nerves such as neck pain radiating down the arm. Back pain radiating down the leg, hip pain radiating down the leg, Numb hands and feet, musculoskeletal Pain Or Pain from a herniated disc over a nerve.
- Pain characteristics include numbness, tingling Pain, and Pain like being stabbed by a needle. Pain like an insect, Pain like an electric shock, etc.
- Has been treated with standard treatment. But the symptoms have not improved.
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Research studies related to CBD
Studies have shown that CBD works differently from THC because it does not work through cannabinoid receptors. It does not have the same psychoactive effects as THC. CBD is also beneficial in the anti-anxiety effect caused by THC because it works against THC’s CB1 receptors. Several studies have shown that CBD may have the potential to reduce spasticity in people. Patients with multiple anti-inflammatory sclerosis in spinal cord injury may have the potential for the treatment of Parkinson’s and cancer. Accepts many types of serotonin receptors. Glycin Receptors and Receptors Affecting Calcium levels in cells, high levels of CBD can stimulate TRVP1 and TRVP2 and inhibit AEA intracellular and AEA breakdown.
There is also a study on the pharmacological effects of CBD, and it was found that it can help prevent and treat the symptoms of various diseases as follows:
Analgesic effect: Oromucosal spray, Nabiximols, a combination of THC and CBD, has been formulated to help reduce rheumatoid arthritis, but for chronic Pain in cancer patients, it is also effective. There is no clear clinical conclusion.
Helps control epilepsy. There have been animal trials using CBD, which is effective against seizures. (Anticonvulsant) and no neurotoxicity. Subsequently, clinical trials were conducted on patients who experienced uncontrollable seizures. When anticonvulsants were given with 200-300 mg of CBD daily for 8-18 weeks, 37% of the patients had no episodes throughout the study, and another 37% showed significant improvement. However, side effects occur in people taking CBD, causing drowsiness.
Further research using CBD alone has allowed us to understand the mechanism of action of CBD better. In a clinical study of Epidolex® (GW Pharmaceuticals), CBD shop Schweiz which contains CBD as the active ingredient, it was found to be used to treat non-convulsive seizures. It can be controlled with intractable epilepsy, such as Dravet and Lennox-Gastaut syndromes, and was approved by the US FDA in November 2018 for treating both types of seizures.
Drug interactions with CBD. Effects on P-glycoprotein (P-GP), an efflux transporter that influences drug resistance in various cancers. CBD inhibits P-GP ATPase in several cancer cell lines. It interferes with the reflux of many cancer drugs, including methotrexate, tyrosine kinase inhibitors (e.g. dasatinib), taxanes (e.g. paclitaxel), and vinca-alkaloids (e.g. vincristine), topoisomerase inhibitors (e.g. irinotecan), intercalants (e.g. doxorubicin).
Effects on a protein called breast cancer resistance protein (BCRP), associated with drug resistance in breast cancer by inhibiting this protein. It is effective against many cancer drugs, including methotrexate, cyclophosphamide, paclitaxel, topotecan, dasatinib, etc. You can buy heart disease CBD medicine online from CBD shop Schweiz.
Multiple CYP effects, such as CYP2C19 inhibitors, affect the metabolites of several drugs that use this enzyme, including cyclophosphamide, imatinib, and lapatinib. Therefore, the concomitant use of CBD with these CYP inhibitors, such as clobazam and diazepam, should be cautioned against dose reduction. Tamoxifen, gefitinib, and imatinib inhibit CYP3A4 and substantially affect many drugs because many drugs are metabolized by this enzyme, including cyclophosphamide, paclitaxel, anastrozole, dasatinib, etc.